Endocrine Abstracts

Introduction: The role of dietary protein in maintaining bone health is controversial. Traditionally the acidifying effect of high dietary protein (HP) has been thought to promote calcium loss from bone and hence hypercalciuria and so was considered harmful compared to a normal protein (NP) diet. However more recently the anabolic effect of increased dietary protein and its effect in increasing calcium absorption have been appreciated. There are no long term prospective clinic...

Recent studies in various species have pointed out that Neurokinin B (NKB), encoded by Tac2 in rodents, and its receptor, NK3R, are important regulators of reproduction. NKB is co-expressed in Kiss1 neurons of the arcuate nucleus (ARC) and stimulates, via auto-regulatory loops, kisspeptin output onto GnRH neurons, therefore stimulating gonadotropin secretion. However, important aspects of the roles of NKB as regulators of the gonadotropic axis remain unknown. We report here th...